Fasciola hepatica, also known as the common liver fluke or sheep liver fluke, is a parasitic. The common liver flukes fasciola hepatica and fasciola gigantica. Fasciola hepatica an overview sciencedirect topics. Therefore, praziquantel therapy is not recommended for fascioliasis. Anthelmintic action of triclabendazole in vivo in juvenile. The common names are the sheep liver fluke and the common liver fluke. Association of fasciola hepatica infection with liver. The eggs pass in feces, hatch in water, and infect lymnaeid snails. Nitazoxanide has been found effective in trials, but is currently not recommended. Pdf the distribution of fasciola hepatica and fasciola gigantica.
Fasciola hepatica infect various animal species, mostly herbivores planteating animals. Doc praktikum fasciola hepatica lekah aini academia. In both groups, peripheral blood mononuclear cell pbmc proliferation in response to the parasitic excretorysecretory products esp showed similar kinetics. Terutama sample yang berasal dari seekor kerbau dari muntilan, jawa tengah menunjukkan variasi yang sangat besar kurniasih, 1995. Fasciola hepatica and fasciola gigantica, as well as hybrids between the two species. Identification and differentiation of fasciola hepatica and. Both species infect the liver tissue of a wide variety of mammals, including humans, in a condition known as fascioliasis. Horses frequently graze the same pastures as sheep and cattle but are thought to be relatively resistant to liver fluke infection 1, 2. The first report of fasciola and liver fibrosis was in 1977. Fasciola hepatica of almost worldwide distribution and the more pathogenic f. Experimental infections of galba truncatula with fasciola gigantica or f.
Partially purified fasciola gigantica worm antigens were evaluated in an enzymefinked immunosorbent assay elisa for the specific serological diagnosis of fascioliasis. In the present study, the effect of in vivo treatment with tcbz on. Fascioliasis due to fasciola hepatica and fasciola gigantica. Immunodetection of fasciola gigantica circulating antigen. Fascioliasis is an important foodborne parasitic disease caused by the two trematode species, fasciola hepatica and fasciola gigantica. A related parasite, fasciola gigantica, also can infect people. It is found in warmer climates asia, africa in cattle and buffalo, in which it is responsible for chronic fasciolosis, and in sheep, in which the disease is frequently acute and fatal. Fasciola gigantica is similar in shape to fasciola hepatica but is longer 75 mm, with less clearly defined shoulders, and is 12 mm wide. Fascioliasis, a food or waterborne trematodiasis due to infection by fasciola hepatica fh or f. A total of 3234 animals have been reported to have concomitant liver fibrosis and fascioliasis including bovine, sheep, calves, and pigs 10 21. The histopathology of fasciola hepatica infections in.
Praziquantel, which is active against most trematodes flukes, typically is not active against fasciola parasites. Causal agent, life cycle, and geographic distribution. It tends to be more oblong with a longer rounded posterior end as compared to broadly pointed posterior end of f. Morphological and molecular discrimination of fasciola species. Fasciolosis is a parasitic worm infection caused by the common liver fluke fasciola hepatica as well as by fasciola gigantica. Parasites fascioliasis fasciola infection fascioliasis is a parasitic infection typically caused by fasciola hepatica, which is also known as the common liver fluke or the sheep liver fluke. Fasciola hepatica and fasciola gigantica are trematode bile duct flukes found primarily in sheep and cattle. Cellular responses to fasciola gigantica and to fasciola hepatica infection in sheep were compared. The growth rate of the parasite, time of entry to the bile ducts, and time of patency are recorded and a preferential migration of the parasite in the liver parenchyma noted. Host responses during experimental infection with fasciola. The phenotypic features of fasciolid adults and eggs infecting buffaloes inhabiting the central punjab area, pakistan, have been studied to. Sensitivity of the lamp assay for detection of fasciola hepatica top and fasciola gigantica bottom using serial dilutions of template dna and visual inspection.
Tube 7 represents a negative control without target dna. Based on the morphometric examination, the flukes belonged to f. Also known as the common liver fluke and sheep liver fluke, fasciola gigantica, is one of two fasciola trematode species to infect the livers of both animals and humans f. A highly sensitive and specific fasciola circulating antigen detection assay, fgca27 elisa, was developed for reliable laboratory diagnosis of human fascioliasis. Simple morphological criteria are unreliable for their specific identification. Amongst the trematodes, this was the first to be discovered by. Fasciola hepatica, also known as the common liver fluke or sheep liver fluke, is a parasitic trematode fluke or flatworm, a type of helminth of the class trematoda, phylum platyhelminthes. Fasciola gigantica in ruminants digestive system merck. Phenotypes of intermediate forms of fasciola hepatica and. Pdf experimental infections of galba truncatula with fasciola gigantica or f. In previous studies, promising phenotypic identification scores were obtained using. The trematodes fasciola hepatica also known as the common liver fluke or the sheep liver fluke and fasciola gigantica are large liver flukes f. In conclusion, a 27kda fasciola antigen was identified in sera of f.
Pdf in east africa, fasciola gigantica is generally the causative agent of fasciolosis but there have been reports of f. Fascioliasis, caused by infection with fasciola hepatica and fasciola gigantica, is said to be the parasitic disease with the greatest latitudinal, longitudinal and altitudinal distribution. Fasciola hepatica and fasciola gigantica are two main species of fasciola which infect both human and animals. Eosinophil numbers increased more quickly and strongly in f. Fascioliasis due to fasciola hepatica and fasciola. In some patients who have biliary tract obstruction, manual extraction of adult flukes e. Experimental infections of lambs with fasciola hepatica are described. Fasciola hepatica liver fluke, is a common and widespread pathogen, well. Fasciolosis, caused by fasciola hepatica temperate species and fasciola gigantica tropical species, is a serious veterinary disease and zoonotic infection worldwide. Molecular and morphological characterization of fasciola spp. Fascioliasis, fasciola hepatica, fasciola gigantica, trematodiasis, neglected tropical diseases, liver fluke.
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